InnovationRx: Stretching Monkeypox Vaccine Doses; Plus, Omicron Subvariant Boosters

Aug 10, 2022   |   Forbes
10% 8/78

As the U.S. continues to face a rise in monkeypox cases (nearly 9,500 cases as of Tuesday), the FDA has okayed a new dosing strategy to stretch vaccine supplies. Bavarian Nordic’s Jynneos vaccine was originally approved by the FDA for a full dose to be administered subcutaneously, meaning underneath the skin into the fat of the arm. On Tuesday, the FDA issued an emergency use authorization that allows healthcare workers to inject one-fifth of a normal dose intradermally, meaning into the skin.

But experts tell Forbes that this new method poses challenges for the vaccine rollout: There is limited data supporting the strategy and most healthcare workers have experience giving intradermal injections. This method could also produce more side effects, like swelling and itching at the injection site, compared to the standard dose, according to Dr. Jay Varma, a professor at Weill Cornell Medicine. Though Varma also said he thinks the new approach is the best one “given the vaccine supply shortage.”

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Katie Jennings

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